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Research Article
Pediatric Sepsis in Resource-limited Settings Etiology Diagnosis, and Evidence-based Treatment Strategies
Barno Shamsuddinovna Makhmudova,
Shaira Khalilovna Atadjanova*
Issue:
Volume 2, Issue 2, April 2026
Pages:
19-24
Received:
20 January 2026
Accepted:
21 February 2026
Published:
4 March 2026
Abstract: Pediatric sepsis remains a critical global health challenge and a leading cause of morbidity and mortality, particularly in neonatal and pediatric intensive care units. It is defined as life-threatening organ dysfunction resulting from a dysregulated host response to infection. This study aimed to analyze the etiology, clinical manifestations, diagnostic indicators, and modern treatment strategies of sepsis in children, with special emphasis on early recognition and evidence-based management in low- and middle-income countries, including Uzbekistan. A retrospective and analytical review of hospital-based pediatric sepsis cases and multicenter clinical studies was conducted. Epidemiological patterns, laboratory biomarkers, pathogen distribution, and therapeutic outcomes were comparatively evaluated. Particular attention was given to antimicrobial therapy timing, hemodynamic stabilization, and intensive care interventions. The findings demonstrate that early empirical antibiotic administration within the first hour significantly reduced mortality rates. Neonates and infants under one year showed the highest vulnerability and case-fatality risk. Elevated C-reactive protein, procalcitonin, and serum lactate levels were strongly associated with disease severity and progression to septic shock. Gram-negative pathogens, particularly Klebsiella pneumoniae and Escherichia coli, predominated in neonatal cases, with increasing antimicrobial resistance observed. Implementation of standardized sepsis treatment protocols improved survival outcomes and reduced hospitalization duration. In conclusion, early diagnosis, biomarker-guided risk stratification, and protocol-based management are decisive factors in improving pediatric sepsis outcomes. Strengthening intensive care capacity, laboratory diagnostics, and antimicrobial stewardship programs is essential for reducing child mortality associated with sepsis in resource-limited healthcare systems.
Abstract: Pediatric sepsis remains a critical global health challenge and a leading cause of morbidity and mortality, particularly in neonatal and pediatric intensive care units. It is defined as life-threatening organ dysfunction resulting from a dysregulated host response to infection. This study aimed to analyze the etiology, clinical manifestations, diag...
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Research Article
Navigating Regulatory Compliance in Go-to-Market Strategies for MedTech Startups in the DACH Region
Abu Yusuf Mohammad Habibur Rahman*
Issue:
Volume 2, Issue 2, April 2026
Pages:
25-31
Received:
10 December 2025
Accepted:
24 February 2026
Published:
10 March 2026
DOI:
10.11648/j.ajmst.20260202.12
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Views:
Abstract: This article examines the significant Go-to-Market (GTM) hurdles for medical technology (MedTech) startups operating in the DACH region, which includes Germany, Austria, and Switzerland. Market entry in this territory is heavily influenced by a rigorous regulatory framework consisting of the EU Medical Device Regulation (MDR), the In Vitro Diagnostic Regulation (IVDR), and the General Data Protection Regulation (GDPR). The research identifies that these startups often struggle with internal capacity to manage such multifaceted requirements, resulting in substantial product launch delays and heightened operational costs. For example, more than 70% of German MedTech startups have reported GTM delays specifically due to bottlenecks related to the MDR. The study highlights that the MDR, enforced since 2021, introduced stricter clinical evaluation needs and mandatory engagement with notified bodies, which has strained existing capacities and doubled review timelines in some instances. To navigate these challenges, the article explores the strategic integration of management technologies. This includes the use of regulatory information management systems, quality management software, and project management tools designed to improve the efficiency and effectiveness of GTM execution. A notable real-time use case utilizes Natural Language Processing (NLP) and Large Language Models (LLMs) to automate MDR documentation, reportedly reducing compliance preparation time by 70%. Ultimately, the research suggests that by embedding regulatory milestones directly into launch roadmaps and utilizing Regulatory Technology (RegTech) solutions, MedTech startups can transform compliance from a formidable barrier into a strategic competitive advantage within the DACH region.
Abstract: This article examines the significant Go-to-Market (GTM) hurdles for medical technology (MedTech) startups operating in the DACH region, which includes Germany, Austria, and Switzerland. Market entry in this territory is heavily influenced by a rigorous regulatory framework consisting of the EU Medical Device Regulation (MDR), the In Vitro Diagnost...
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Research Article
A Comprehensive Assessment of Post-COVID-19 Changes and Its Correction with the Help of G. Lucidum and Alkhaday
Abilov Pulat Mеlisovich*
Issue:
Volume 2, Issue 2, April 2026
Pages:
32-56
Received:
30 December 2025
Accepted:
8 January 2026
Published:
10 March 2026
DOI:
10.11648/j.ajmst.20260202.13
Downloads:
Views:
Abstract: In December 2019, a series of acute respiratory illnesses characterized by rapid worsening of symptoms, pneumonia, acute respiratory distress syndrome (ARDS), and in some cases, death were observed in Wuhan City, Hubei Province, China. To achieve the set objective, the results of treatment of 100 sexually mature rats of both sexes with coronavirus infection caused by COVID -19 were analyzed. All animals were divided into groups: Group 1 - animals with coronavirus infection with a confirmed positive PCR test, treated with ivermectin at a dosage of 300 mg of body weight (n = 25), Group 2 - animals with coronavirus infection treated with baicalin at a dosage of 500 mg (n = 25), Group 3 - animals with coronavirus infection treated with molnupiravir 25 mg / kg of body weight (n = 25), Group 4 - animals with coronavirus infection treated with a new drug based on G. lucidum and black cumin (n = 25). Lymphocytic myocarditis was detected in all rats (100%). Dystrophic changes in cardiomyocytes were also detected in 57.4% of cases, apoptotic bodies in 29.41% of cases, uneven cardiomyocyte hypertrophy in 85.29% of cases, and lipofuscinosis in 45.59% of cases. Subendocardial lipomatosis in the cardiac conduction system was observed in 51.47% of cases. The average percentage of lipomatosis area from the micrograph area was 2.47±3.12%. The area under the curve (AUC) = 0.91 (95% CI = 0.85-0.98). The prediction accuracy of the prognostic model was 91.7%, sensitivity was 0.87%, and specificity was 0.95%. AUC was 0.91 (95% CI = 0.85-0.98), p < 0.001.
Abstract: In December 2019, a series of acute respiratory illnesses characterized by rapid worsening of symptoms, pneumonia, acute respiratory distress syndrome (ARDS), and in some cases, death were observed in Wuhan City, Hubei Province, China. To achieve the set objective, the results of treatment of 100 sexually mature rats of both sexes with coronavirus ...
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